In 2004, MSD Animal Health obtained a licence for a dog vaccine with a three year duration of immunity against parvovirus, hepatitis and distemper. Vets using this vaccine - Nobivac® DHPPi - are now able to protect dogs using far fewer vaccine components, as shown below.
Please note that protection against leptospirosis still requires an annual vaccination with Nobivac® Lepto 2 or equivalent.
| 6-8 weeks | Nobivac DHPPi + Nobivac Lepto 2 |
| 10 weeks | Nobivac DHPPi + Nobivac Lepto 2 |
| 1st annual booster | Nobivac DHPPi + Nobivac Lepto 2 |
| 2nd annual booster | Nobivac® Pi + Nobivac Lepto 2 |
| 3rd annual booster | Nobivac Pi + Nobivac Lepto 2 |
| 4th annual booster | Nobivac DHPPi + Nobivac Lepto 2 |
| 5th annual booster | Nobivac Pi + Nobivac Lepto 2 |
| 6th annual booster | Nobivac Pi + Nobivac Lepto 2 |
| 7th annual booster | Nobivac DHPPi + Nobivac Lepto 2 |
| etc |